Mechanisms of vitamin D in regulation of calcium binding protein

Calbindin 9K(CaBP-9k)and Calbindin 28K(CaBP-28k), vitamin D dependent calcium binding protein(CaBP), play an important role in the the process of active transport of calcium.Research has shown that vitamin D can increase the expression of calcium binding protein, which can promote the absorption of calcium ions.Vitamin D deficiency and calcium binding protein could cause disorders of calcium homeostasis, such as hypocalcemia, rickets, osteoporosis and many other diseases.This review summarizes the studies of structure and distribution of CaBP and the mechanism of vitamin D in regulation of CaBP, which might provide new strategies for the prevention and treatment of paraplasia ossium. Key words: Calbinding; Vitamin D; Calcium; Transport