荧光
材料科学
癌细胞
谷胱甘肽
检出限
光致发光
碳纤维
发光
量子点
纳米技术
光电子学
癌症
化学
生物化学
光学
生物
物理
复合数
复合材料
酶
遗传学
色谱法
作者
Lin Li,Lihong Shi,Jing Jia,Omer Eltayeb,Wenjing Lu,Youhong Tang,Chuan Dong,Shaomin Shuang
标识
DOI:10.1021/acsami.0c00283
摘要
We developed a facile strategy for the fabrication of dual-emission carbon nanodots (CDs) and demonstrated their applications for ratiometric glutathione (GSH) sensing and for differentiating cancer cells from normal cells. Dual-emission CDs were synthesized using a simple hydrothermal treatment of alizarin carmine as the carbon source, manifesting intriguing dual-emission behavior at 430 and 642 nm. With increasing GSH concentration, the fluorescence band at 430 nm increased gradually, whereas that at 642 nm decreased slightly. With monitoring of the intrinsic ratiometric fluorescence variation (I430nm/I642nm), as-prepared CDs were developed as an effective platform for ratiometric fluorescent GSH sensing, with a linear range of 1–10 to 25–150 μM and a detection limit of 0.26 μM. More importantly, confocal fluorescent imaging of cancer cells and normal cells indicated that obtained CDs could be implemented as an effective tool to visualize cancer cells with overexpressing GSH.
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