胸腺基质淋巴细胞生成素
医学
哮喘
单克隆抗体
发病机制
免疫学
细胞因子
间质细胞
抗体
病理
作者
Andrew Menzies‐Gow,Jonathan Corren,Arnaud Bourdin,Geoffrey Chupp,Elliot Israel,Michael E. Wechsler,Christopher E. Brightling,Janet M. Griffiths,Åsa Hellqvist,Karin Bowen,Primal Kaur,Gun Almqvist,Sandhia Ponnarambil,Gene Colice
标识
DOI：10.1056/nejmoa2034975
摘要
Tezepelumab is a human monoclonal antibody that blocks thymic stromal lymphopoietin, an epithelial-cell–derived cytokine implicated in the pathogenesis of asthma. The efficacy and safety of tezepelumab in patients with severe, uncontrolled asthma require further assessment.
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