抗辐射性
DNA修复
癌症研究
雷达50
辐射敏感性
放射治疗
DNA损伤
癌症
电离辐射
癌细胞
核酸酶
生物信息学
医学
生物
DNA
遗传学
转录因子
内科学
DNA结合蛋白
基因
核物理学
物理
辐照
作者
Yen‐Yun Wang,Amos C. Hung,Steven Lo,Ya-Ching Hsieh,Shyng‐Shiou F. Yuan
标识
DOI:10.1016/j.canlet.2021.05.013
摘要
MRE11, the core of the MRE11/RAD50/NBS1 complex, is one of key DNA damage response proteins. Increasing evidence suggests that its expression in cancer cells is critical to developing radioresistance; as such, MRE11 is an emerging marker for targeted radiosensitization strategies. Elevated MRE11 in tumor tissues has been associated with poor survival in patients undergoing radiotherapy, although in some cancer types, the opposite has been noted. The recent discovery of ionizing radiation-induced truncation of MRE11, which decreases its efficacy, may explain some of these paradoxical findings. The progress of research on the biological modulation of MRE11 expression is also discussed, with the potential application of small molecule or large molecule inhibitors of MRE11 for enhancing radiosensitivity. Current research has further highlighted both nuclease and non-nuclease activities of MRE11 in cancer cells treated with ionizing radiation, and differentiation between these is essential to verify the targeting effects of radiosensitizing agents. These updates clarify our understanding of how MRE11 expression may be utilized in future stratification of cancer patients for radiotherapy, and how it may be leveraged in shaping novel radiosensitization strategies.
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