材料科学
光动力疗法
姜黄素
光子上转换
纳米颗粒
阿霉素
单线态氧
药物输送
纳米技术
核化学
光化学
兴奋剂
光电子学
化疗
药理学
氧气
化学
医学
有机化学
外科
作者
Xiaoling Qi,Yingdong Han,Shujing Liu,Haofeng Hu,Zhenzhou Cheng,Tiegen Liu
出处
期刊:Nanotechnology
[IOP Publishing]
日期:2021-04-01
卷期号:32 (25): 255703-255703
被引量:4
标识
DOI:10.1088/1361-6528/abecba
摘要
Stimulus-triggered drug delivery systems (DDSs) based on lanthanide-doped upconversion nanoparticles (UCNPs) have attracted significant attention for treating cancers due to their merits of high drug availability, precisely controlled drug release, and low side-effects. However, such DDSs usually exhibit a single stimulus-response, which may limit the efficiency of cancer treatment. To extend response types in a single DDS, we construct NaYF4:Yb/Tm@SiO2-doxorubicin (Dox)/curcumin (Cur)-chitosan (CS)/2-Octen-1-ylsuccinic anhydride (OSA) nanoparticles with core-shell structures. Our method is based on the exploration of the synergistic effect of UCNPs and multiple drugs. In particular, the NaYF4:Yb/Tm is used to convert near-infrared light to visible light, activating Cur photosensitizers to produce singlet oxygen for photodynamic therapy, while CS/OSA responds to a low pH environment to release cancer drugs, including Dox and Cur for chemotherapy through breaking a free carboxyl group. The results show that the UCNPs with a 40 nm diameter, 23 nm thick mesoporous SiO2, and 19/1 mol% Yb3+/Tm3+concentrations could continuously release Dox and Cur at a pH value of 6.5 within 6 h after the excitation of a 980 nm-wavelength CW laser. Our study provides a promising approach for developing efficient DDSs for cancer treatment.
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