生物
细胞生物学
表观遗传学
染色质免疫沉淀
遗传学
组蛋白
染色质
DNA甲基化
组蛋白甲基化
组蛋白甲基转移酶
二价染色质
斑马鱼
干细胞
胚胎干细胞
染色质重塑
表观遗传学
组蛋白H2A
计算生物学
组蛋白H3
诱导多能干细胞
组蛋白密码
重编程
细胞分化
基因
基因表达调控
表观基因组
基因表达
发起人
作者
Alissa D Marchione,Zanshe Thompson,Katie L. Kathrein
出处
期刊:Briefings in Functional Genomics
[Oxford University Press]
日期:2021-03-30
被引量:3
摘要
The complex processes necessary for embryogenesis require a gene regulatory network that is complex and systematic. Gene expression regulates development and organogenesis, but this process is altered and fine-tuned by epigenetic regulators that facilitate changes in the chromatin landscape. Epigenetic regulation of embryogenesis adjusts the chromatin structure by modifying both DNA through methylation and nucleosomes through posttranslational modifications of histone tails. The zebrafish is a well-characterized model organism that is a quintessential tool for studying developmental biology. With external fertilization, low cost and high fecundity, the zebrafish are an efficient tool for studying early developmental stages. Genetic manipulation can be performed in vivo resulting in quick identification of gene function. Large-scale genome analyses including RNA sequencing, chromatin immunoprecipitation and chromatin structure all are feasible in the zebrafish. In this review, we highlight the key events in zebrafish development where epigenetic regulation plays a critical role from the early stem cell stages through differentiation and organogenesis.
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