生物膜
化学
氨基酸
金黄色葡萄球菌
微生物学
细菌
最小抑制浓度
抑制性突触后电位
生物活性
体外
生物化学
生物
遗传学
神经科学
作者
Kentaro Ikeda,Takuji Shoda,Yosuke Demizu,Genichiro Tsuji
标识
DOI:10.1016/j.bmcl.2021.128259
摘要
Bacterial biofilms often cause medical complications and there has been a great deal of interest in the discovery of small-molecule agents that can inhibit the formation of biofilms. Among these agents, it has been reported that several d-amino acids, such as d-Leu, d-Trp, d-Tyr, and d-Met, exhibit weak inhibitory activity toward bacterial biofilm formation. In this study, we have screened a library of 332 non-proteinogenic amino acids for new biofilm inhibitory agents and discovered several compounds exhibiting biofilm-inhibitory activity against Gram-positive bacteria. In particular, H-DL-β-(3,4-dihydroxyphenyl)-dl-Ser-OH (253) showed potent activity against S. aureus, including methicillin-resistant S. aureus.
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