生物
先天免疫系统
效应器
先天性淋巴细胞
免疫学
细胞生物学
自然杀伤细胞
免疫
获得性免疫系统
免疫系统
淋巴因子激活杀伤细胞
白细胞介素21
细胞毒性T细胞
T细胞
遗传学
体外
作者
Adriana M. Mujal,Rebecca B. Delconte,Joseph C. Sun
出处
期刊:Annual Review of Immunology
[Annual Reviews]
日期:2021-04-26
卷期号:39 (1): 417-447
被引量:120
标识
DOI:10.1146/annurev-immunol-101819-074948
摘要
Natural killer (NK) cells are innate lymphocytes that provide critical host defense against pathogens and cancer. Originally heralded for their early and rapid effector activity, NK cells have been recognized over the last decade for their ability to undergo adaptive immune processes, including antigen-driven clonal expansion and generation of long-lived memory. This review presents an overview of how NK cells lithely partake in both innate and adaptive responses and how this versatility is manifest in human NK cell–mediated immunity.
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