亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Outcomes in Patients with Diabetes Mellitus According to Insulin Treatment After Percutaneous Coronary Intervention in the Second-Generation Drug-Eluting Stent Era

医学 经皮冠状动脉介入治疗 传统PCI 内科学 心脏病学 危险系数 心肌梗塞 糖尿病 人口 血运重建 置信区间 环境卫生 内分泌学
作者
Seung-Hoon Pi,Tae‐Min Rhee,Joo Myung Lee,Doyeon Hwang,Jonghanne Park,Taek Kyu Park,Jeong Hoon Yang,Young Bin Song,Jin‐Ho Choi,Joo‐Yong Hahn,Byung Jin Kim,Bum Soo Kim,Hyeon–Cheol Gwon,Seung‐Hyuk Choi
出处
期刊:American Journal of Cardiology [Elsevier BV]
卷期号:121 (12): 1505-1511 被引量:25
标识
DOI:10.1016/j.amjcard.2018.02.034
摘要

Limited data exist regarding the clinical outcomes of patients with diabetes mellitus (DM) after percutaneous coronary intervention (PCI) using second-generation drug-eluting stents (DES), especially according to DM treatment. The purpose of this study was to compare clinical outcomes among patients without DM, with non-insulin-treated DM (non-ITDM), and with ITDM after PCI using second-generation DES. We analyzed 4,812 consecutive patients who underwent PCI using second-generation DES. Primary outcomes were patient-oriented composite outcome (a composite of all-cause mortality, any myocardial infarction, and any revascularization) at 3 years. Among the total population, 3,026 patients have no DM, 1,169 have non-ITDM, and 617 have ITDM. Patients with DM, regardless of non-ITDM and ITDM, showed significantly higher risk of patient-oriented composite outcome (21.0% vs 14.5%; adjusted hazard ratio [HRadj]1.41, 95% confidence interval [CI] 1.19 to 1.66, p <0.001), mainly driven by significantly higher risk of cardiac death and any revascularization compared with non-DM. Among DM population, ITDM showed significantly higher risk of cardiac death (7.7% vs 3.7%; HRadj 1.97, 95% CI 1.19 to 3.27, p = 0.009), any revascularization (17.0% vs 11.4%; HRadj 1.40, 95% CI 1.01 to 1.93, p = 0.041), and definite/probable stent thrombosis (1.7% vs 0.7%; HRadj 2.80, 95% CI 1.04 to 7.56, p = 0.042) compared with non-ITDM. In conclusion, even in the era of second-generation DES, patients with DM are at significantly higher risk of patient-oriented adverse events. Among these, patients with ITDM showed the highest risk of adverse events, mainly driven by higher risk of mortality, any revascularization, and definite/probable stent thrombosis. Limited data exist regarding the clinical outcomes of patients with diabetes mellitus (DM) after percutaneous coronary intervention (PCI) using second-generation drug-eluting stents (DES), especially according to DM treatment. The purpose of this study was to compare clinical outcomes among patients without DM, with non-insulin-treated DM (non-ITDM), and with ITDM after PCI using second-generation DES. We analyzed 4,812 consecutive patients who underwent PCI using second-generation DES. Primary outcomes were patient-oriented composite outcome (a composite of all-cause mortality, any myocardial infarction, and any revascularization) at 3 years. Among the total population, 3,026 patients have no DM, 1,169 have non-ITDM, and 617 have ITDM. Patients with DM, regardless of non-ITDM and ITDM, showed significantly higher risk of patient-oriented composite outcome (21.0% vs 14.5%; adjusted hazard ratio [HRadj]1.41, 95% confidence interval [CI] 1.19 to 1.66, p <0.001), mainly driven by significantly higher risk of cardiac death and any revascularization compared with non-DM. Among DM population, ITDM showed significantly higher risk of cardiac death (7.7% vs 3.7%; HRadj 1.97, 95% CI 1.19 to 3.27, p = 0.009), any revascularization (17.0% vs 11.4%; HRadj 1.40, 95% CI 1.01 to 1.93, p = 0.041), and definite/probable stent thrombosis (1.7% vs 0.7%; HRadj 2.80, 95% CI 1.04 to 7.56, p = 0.042) compared with non-ITDM. In conclusion, even in the era of second-generation DES, patients with DM are at significantly higher risk of patient-oriented adverse events. Among these, patients with ITDM showed the highest risk of adverse events, mainly driven by higher risk of mortality, any revascularization, and definite/probable stent thrombosis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
15秒前
16秒前
silence发布了新的文献求助10
23秒前
silence完成签到,获得积分20
28秒前
量子星尘发布了新的文献求助10
31秒前
yx_cheng应助科研通管家采纳,获得10
58秒前
赘婿应助科研通管家采纳,获得10
59秒前
1分钟前
1分钟前
lu发布了新的文献求助10
1分钟前
怕孤单的幼荷完成签到 ,获得积分10
1分钟前
可爱的函函应助lu采纳,获得10
1分钟前
量子星尘发布了新的文献求助10
1分钟前
1分钟前
2分钟前
muasa发布了新的文献求助10
2分钟前
2分钟前
玩命的大侠完成签到,获得积分10
2分钟前
2分钟前
善良的冰颜完成签到 ,获得积分10
2分钟前
健壮的花瓣完成签到 ,获得积分10
2分钟前
yx_cheng应助科研通管家采纳,获得10
2分钟前
3分钟前
Ava应助CMY采纳,获得10
3分钟前
Sandy举报yan求助涉嫌违规
3分钟前
Qian完成签到 ,获得积分10
3分钟前
Kashing完成签到,获得积分10
3分钟前
小透明发布了新的文献求助10
3分钟前
量子星尘发布了新的文献求助10
3分钟前
Sandy举报卷筒洗衣机求助涉嫌违规
3分钟前
sleet完成签到 ,获得积分10
3分钟前
4分钟前
摇摇奶昔完成签到,获得积分20
4分钟前
Everything发布了新的文献求助10
4分钟前
田様应助科研通管家采纳,获得10
4分钟前
yx_cheng应助科研通管家采纳,获得10
4分钟前
量子星尘发布了新的文献求助200
5分钟前
Everything完成签到,获得积分10
5分钟前
像个间谍发布了新的文献求助10
6分钟前
6分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Social Research Methods (4th Edition) by Maggie Walter (2019) 2390
A new approach to the extrapolation of accelerated life test data 1000
北师大毕业论文 基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 390
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Robot-supported joining of reinforcement textiles with one-sided sewing heads 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4008151
求助须知:如何正确求助?哪些是违规求助? 3547956
关于积分的说明 11298612
捐赠科研通 3282865
什么是DOI,文献DOI怎么找? 1810219
邀请新用户注册赠送积分活动 885957
科研通“疑难数据库(出版商)”最低求助积分说明 811188