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Preparation of chitosan-collagen-alginate composite dressing and its promoting effects on wound healing

壳聚糖 伤口愈合 复合数 肿胀 的 化学 生物医学工程 材料科学 外科 医学 复合材料 生物化学
作者
Haixia Xie,Xiuli Chen,Shen Xianrong,Ying He,Wei Chen,Qun Luo,Weihong Ge,Wei-Hong Yuan,Xue Tang,Deng-Yong Hou,Ding-wen Jiang,Qingrong Wang,Yuming Liu,Qiong Liu,Kexian Li
出处
期刊:International Journal of Biological Macromolecules [Elsevier BV]
卷期号:107: 93-104 被引量:147
标识
DOI:10.1016/j.ijbiomac.2017.08.142
摘要

The present study aimed to prepare a composite dressing composed of collagen, chitosan, and alginate, which may promote wound healing and prevent from seawater immersion. Chitosan-collagen-alginate (CCA) cushion was prepared by paintcoat and freeze-drying, and it was attached to a polyurethane to compose CCA composite dressing. The swelling, porosity, degradation, and mechanical properties of CCA cushion were evaluated. The effects on wound healing and seawater prevention of CCA composite dressing were tested by rat wound model. Preliminary biosecurity was tested by cytotoxicity and hemocompatibility. The results revealed that CCA cushion had good water absorption and mechanical properties. A higher wound healing ratio was observed in CCA composite dressing treated rats than in gauze or chitosan treated ones. On the fifth day, the healing rates of CCA composite dressing, gauze, and chitosan were 48.49%±1.07%, 28.02%±6.4%, and 38.97%±8.53%, respectively. More fibroblast and intact re-epithelialization were observed in histological images of CCA composite dressing treated rats, and the expressions of EGF, bFGF, TGF-β, and CD31 increased significantly. CCA composite dressing showed no significant cytotoxicity, and favorable hemocompatibility. These results suggested that CCA composite dressing could prevent against seawater immersion and promote wound healing while having a good biosecurity.
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