Going around in circles: virulence plasmids in enteric pathogens

Plasmids have a major role in the development of disease caused by enteric bacterial pathogens. Virulence plasmids are usually large (>40 kb) low copy elements and encode genes that promote host–pathogen interactions. Although virulence plasmids provide advantages to bacteria in specific conditions, they often impose fitness costs on their host. In this Review, we discuss virulence plasmids in Enterobacteriaceae that are important causes of diarrhoea in humans, Shigella spp., Salmonella spp., Yersinia spp and pathovars of Escherichia coli. We contrast these plasmids with those that are routinely used in the laboratory and outline the mechanisms by which virulence plasmids are maintained in bacterial populations. We highlight examples of virulence plasmids that encode multiple mechanisms for their maintenance (for example, toxin–antitoxin and partitioning systems) and speculate on how these might contribute to their propagation and success. Virulence plasmids have a major role in the development of disease that is caused by enteric bacterial pathogens. In this Review, Pilla and Tang discuss virulence plasmids in enteric pathogens, outline the mechanisms by which they are maintained in bacterial populations and speculate on how these might contribute their propagation and success.