免疫系统
肿瘤坏死因子α
灵敏度(控制系统)
逃避(道德)
生物
免疫学
医学
电子工程
工程类
作者
Conor J. Kearney,Stephin J. Vervoort,Simon J. Hogg,Kelly M. Ramsbottom,Andrew J. Freeman,Najoua Lalaoui,Lizzy Pijpers,Jessica Michie,Kristin K. Brown,Deborah A. Knight,Vivien R. Sutton,Paul A. Beavis,Ilia Voskoboinik,Phillip K. Darcy,John Silke,Joseph A. Trapani,Ricky W. Johnstone,Jane Oliaro
出处
期刊:Science immunology
[American Association for the Advancement of Science (AAAS)]
日期:2018-05-04
卷期号:3 (23)
被引量:293
标识
DOI:10.1126/sciimmunol.aar3451
摘要
Whole-genome CRISPR screens identify resistance to TNF-mediated killing by T and NK cells as a tumor immune evasion mechanism.
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