已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Location-specific differences in hematoma volume predict outcomes in patients with spontaneous intracerebral hemorrhage

医学 脑出血 格拉斯哥昏迷指数 脑室出血 改良兰金量表 血肿 接收机工作特性 自发性脑出血 内科学 麻醉 外科 缺血性中风 胎龄 怀孕 缺血 生物 遗传学
作者
Natasha Ironside,Ching‐Jen Chen,Victoria Dreyer,Brandon R. Christophe,Thomas J. Buell,E. Sander Connolly
出处
期刊:International Journal of Stroke [SAGE Publishing]
卷期号:15 (1): 90-102 被引量:31
标识
DOI:10.1177/1747493019830589
摘要

Background and objective Functional outcome after spontaneous intracerebral hemorrhage (ICH) may vary depending on hematoma volume and location. We assessed the interaction between hematoma volume and location, and modified the original ICH score to include such an interaction. Methods Consecutive ICH patients were enrolled in the Intracerebral Hemorrhage Outcomes Project from 2009 to 2017. Inclusion criteria were age≥18 years, baseline modified Rankin Scale (mRS) score 0–2, neuroimaging, and follow-up. Functional dependence and mortality were defined as 90-day mRS>2 and death, respectively. A location ICH score was developed using multivariable regression and area under the receiver operator characteristic curve (AUROC) analyses. Results The study cohort comprised 311 patients, and the derivation and validation cohorts comprised 209 and 102 patients, respectively. Interactions between hematoma volume and location predicted functional dependence ( p = 0.008) and mortality ( p = 0.025). The location ICH score comprised age≥80 years (1 point), Glasgow Coma Scale score (3–9 = 2 points; 10–13 = 1 point), volume–location (lobar:≥24 mL=2 points, 21–24 mL=1 point; deep:≥8 mL=2 points, 7–8 mL=1 point; brainstem:≥6 mL=2 points, 3–6 mL=1 point; cerebellum:≥24 mL=2 points, 12–24 mL=1 point), and intraventricular hemorrhage (1 point). AUROC of the location ICH score was higher in functional dependence (0.883 vs. 0.770, p = 0.002) but not mortality (0.838 vs. 0.841, p = 0.918) discrimination compared to the original ICH score. Conclusions The interaction between hematoma volume and location exerted an independent effect on outcomes. Excellent discrimination of functional dependence and mortality was observed with incorporation of location-specific volume thresholds into a prediction model. Therefore, the volume–location relationship plays an important role in ICH outcome prediction.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
iNk应助Sky36001采纳,获得20
刚刚
龙金兴完成签到 ,获得积分10
刚刚
3秒前
LYSM应助shangjiaGuo采纳,获得30
4秒前
5秒前
5秒前
Akim应助科研通管家采纳,获得10
6秒前
科研通AI2S应助科研通管家采纳,获得10
6秒前
6秒前
我是老大应助科研通管家采纳,获得10
7秒前
英俊的铭应助科研通管家采纳,获得10
7秒前
情怀应助科研通管家采纳,获得30
7秒前
7秒前
9秒前
大模型应助干净又晴采纳,获得10
9秒前
mellow发布了新的文献求助10
9秒前
YCG完成签到 ,获得积分10
9秒前
Amon发布了新的文献求助10
10秒前
称心嫣娆发布了新的文献求助10
11秒前
爆米花应助淡定采纳,获得10
12秒前
洞两完成签到,获得积分10
14秒前
15秒前
Akim应助俏皮的白柏采纳,获得10
15秒前
15秒前
18秒前
bkagyin应助一颗椰子糖耶采纳,获得10
20秒前
天天快乐应助露露采纳,获得10
20秒前
干净又晴发布了新的文献求助10
21秒前
22秒前
22秒前
wkjfh应助Leoniko采纳,获得10
23秒前
帅男发布了新的文献求助10
24秒前
wyp发布了新的文献求助10
25秒前
26秒前
子非鱼发布了新的文献求助10
26秒前
28秒前
阿氏之光发布了新的文献求助10
31秒前
烟花应助自由的读书人采纳,获得10
31秒前
酷炫抽屉完成签到 ,获得积分10
31秒前
32秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989797
求助须知:如何正确求助?哪些是违规求助? 3531914
关于积分的说明 11255516
捐赠科研通 3270597
什么是DOI,文献DOI怎么找? 1805008
邀请新用户注册赠送积分活动 882181
科研通“疑难数据库(出版商)”最低求助积分说明 809190