间质细胞
肿瘤微环境
网状细胞
淋巴结间质细胞
淋巴瘤
淋巴结
生物
间充质干细胞
骨髓
病理
血管生成
癌症研究
滤泡树突状细胞
滤泡性淋巴瘤
免疫学
脾脏
医学
细胞生物学
T细胞
抗原提呈细胞
免疫系统
作者
Marzenna Blonska,Nitin Agarwal,Francisco Vega
标识
DOI:10.1016/j.semcancer.2015.03.002
摘要
Lymphomas develop and progress in a specialized tissue microenvironment such as bone marrow as well as secondary lymphoid organs such as lymph node and spleen. The lymphoma microenvironment is characterized by a heterogeneous population of stromal cells, including fibroblastic reticular cells, nurse-like cells, mesenchymal stem cells, follicular dendritic cells, and inflammatory cells such as macrophages, T- and B-cells. These cell populations interact with the lymphoma cells to promote lymphoma growth, survival and drug resistance through multiple mechanisms. Angiogenesis is also recognized as an important factor associated with lymphoma progression. In recent years, we have learned that the interaction between the malignant and non-malignant cells is bidirectional and resembles, at least in part, the pattern seen between non-neoplastic lymphoid cells and the normal microenvironment of lymphoid organs. A summary of the current knowledge of lymphoma microenvironment focusing on the cellular components will be reviewed here.
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