化学
氰化
钯
卤化
螯合作用
催化作用
级联
药物化学
组合化学
有机化学
色谱法
作者
Xiaofei Jia,Dongpeng Yang,Wenhui Wang,Fang Luo,Jiang Cheng
摘要
A chelation-assisted palladium-catalyzed cascade bromination/cyanation reaction of 2-arylpyridine and 1-arylpyrazole C−H bonds has been developed. Notably, the reaction employs K3[Fe(CN)6] as a safe and nontoxic cyanide source, providing aromatic nitriles in moderate to good yields in one-pot. The procedure tolerates methoxy, chloro, fluoro, cyano, trifluoromethyl, and carbomethoxy groups.
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