基因座(遗传学)
生物
遗传学
基因
T细胞受体
人类基因组
重复序列
分子生物学
基因组
DNA
T细胞
免疫系统
作者
Lee Rowen,Ben F. Koop,Leroy Hood
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1996-06-21
卷期号:272 (5269): 1755-1762
被引量:419
标识
DOI:10.1126/science.272.5269.1755
摘要
The human β T cell receptor (TCR) locus, comprising a complex family of genes, has been sequenced. The locus contains two types of coding elements—TCR elements (65 variable gene segments and two clusters of diversity, joining, and constant segments) and eight trypsinogen genes—that constitute 4.6 percent of the DNA. Genome-wide interspersed repeats and locus-specific repeats span 30 and 47 percent, respectively, of the 685-kilobase sequence. A comparison of the germline variable elements with their approximately 300 complementary DNA counterparts reveals marked differential patterns of variable gene expression, the importance of exonuclease activity in generating TCR diversity, and the predominant tendency for only functional variable elements to be present in complementary DNA libraries.
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