线粒体
细胞生物学
生物发生
生物
细胞器
功能(生物学)
粒体自噬
线粒体融合
细胞器生物发生
线粒体生物发生
程序性细胞死亡
真核细胞
平衡
细胞
细胞凋亡
线粒体DNA
遗传学
自噬
基因
作者
Christina Ploumi,Ioanna Daskalaki,Nektarios Tavernarakis
出处
期刊:FEBS Journal
[Wiley]
日期:2016-08-11
卷期号:284 (2): 183-195
被引量:322
摘要
Mitochondria are semi-autonomous organelles of prokaryotic origin that are postulated to have been acquired by eukaryotic cells through an early endosymbiotic event. Except for their main role in energy production, they are also implicated in fundamental cellular processes, including ion homeostasis, lipid metabolism, and initiation of apoptotic cell death. Perturbed mitochondrial function has been correlated with severe human pathologies such as type-2 diabetes, cardiovascular, and neurodegenerative diseases. Thus, proper mitochondrial physiology is a prerequisite for health and survival. Cells have developed sophisticated and elaborate mechanisms to adapt to stress conditions and alterations in metabolic demands, by regulating mitochondrial number and function. Hence, the generation of new and the removal of damaged or unwanted mitochondria are highly regulated processes that need to be accurately coordinated for the maintenance of mitochondrial and cellular homeostasis. Here, we survey recent research findings that advance our understanding and highlight the importance of the underlying molecular mechanisms.
科研通智能强力驱动
Strongly Powered by AbleSci AI