纳米载体
转铁蛋白
药物输送
背景(考古学)
靶向给药
转铁蛋白受体
靶向治疗
医学
纳米医学
毒品携带者
癌症研究
化学
阿霉素
癌细胞
内吞作用
药品
纳米颗粒
癌症
体内
细胞毒性
脂质体
光热治疗
纳米技术
共轭体系
基因传递
药理学
生物
材料科学
内科学
古生物学
作者
Daniele Rubert Nogueira-Librelotto,Cristiane Franco Codevilla,Ammad Ahmad Farooqı,Clarice Madalena Bueno Rolim
标识
DOI:10.2174/1381612822666161026162347
摘要
A lot of effort has been devoted to achieving active targeting for cancer therapy in order to reach the right cells. Hence, increasingly it is being realized that active-targeted nanocarriers notably reduce off-target effects, mainly because of targeted localization in tumors and active cellular uptake. In this context, by taking advantage of the overexpression of transferrin receptors on the surface of tumor cells, transferrin-conjugated nanodevices have been designed, in hope that the biomarker grafting would help to maximize the therapeutic benefit and to minimize the side effects. Notably, active targeting nanoparticles have shown improved therapeutic performances in different tumor models as compared to their passive targeting counterparts. In this review, current development of nano-based devices conjugated with transferrin for active tumor-targeting drug delivery are highlighted and discussed. The main objective of this review is to provide a summary of the vast types of nanomaterials that have been used to deliver different chemotherapeutics into tumor cells, and to ultimately evaluate the progression on the strategies for cancer therapy in view of the future research.
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