Continuous separation of multiple size microparticles using alternating current dielectrophoresis in microfluidic device with acupuncture needle electrodes

微流控 介电泳 材料科学 体积流量 粒径 电极 纳米技术 电压 制作 粒子(生态学) 实验室晶片 分离(统计) 微流控芯片 聚苯乙烯 电场 复合材料 电气工程 计算机科学 机械 聚合物 化学工程 化学 工程类 量子力学 替代医学 机器学习 医学 物理化学 病理 海洋学 地质学 物理
作者
Ye Tao,Yukun Ren,Hui Yan,Hongyuan Jiang
出处
期刊:Chinese journal of mechanical engineering [Elsevier]
卷期号:29 (2): 325-331 被引量:9
标识
DOI:10.3901/cjme.2015.1028.128
摘要

The need to continuously separate multiple microparticles is required for the recent development of lab-on-chip technology. Dielectrophoresis(DEP)-based separation device is extensively used in kinds of microfluidic applications. However, such conventional DEP-based device is relatively complicated and difficult for fabrication. A concise microfluidic device is presented for effective continuous separation of multiple size particle mixtures. A pair of acupuncture needle electrodes are creatively employed and embedded in a PDMS(poly-dimethylsiloxane) hurdle for generating non-uniform electric field thereby achieving a continuous DEP separation. The separation mechanism is that the incoming particle samples with different sizes experience different negative DEP(nDEP) forces and then they can be transported into different downstream outlets. The DEP characterizations of particles are calculated, and their trajectories are numerically predicted by considering the combined action of the incoming laminar flow and the nDEP force field for guiding the separation experiments. The device performance is verified by successfully separating a three-sized particle mixture, including polystyrene microspheres with diameters of 3 μm, 10 μm and 25 μm. The separation purity is below 70% when the flow rate ratio is less than 3.5 or more than 5.1, while the separation purity can be up to more than 90% when the flow rate ratio is between 3.5 and 5.1 and meanwhile ensure the voltage output falls in between 120 V and 150 V. Such simple DEP-based separation device has extensive applications in future microfluidic systems.

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