Airway Aging and Methylation Disruptions in HIV-associated Chronic Obstructive Pulmonary Disease.

慢性阻塞性肺病 DNA甲基化 表观遗传学 医学 甲基化 人口 免疫学
作者
Ana I Hernández Cordero,Chen Xi Yang,Julia Yang,Steven Horvath,Tawimas Shaipanich,Julia MacIsaac,David Ts Lin,Michael S Kobor,Silvia Guillemi,Marianne Harris,Wan Lam,Stephen Lam,Julio Montaner,S F Paul Man,Don D Sin,Janice M Leung
出处
期刊:American Journal of Respiratory and Critical Care Medicine [American Thoracic Society]
标识
DOI:10.1164/rccm.202106-1440oc
摘要

Age-related diseases like chronic obstructive pulmonary disease (COPD) occur at higher rates in people living with human immunodeficiency virus (PLWH), than in uninfected populations.To identify whether accelerated aging can be observed in the airways of PLWH with COPD, manifest by a unique DNA methylation signature.Bronchial epithelial brushings from PLWH with and without COPD and HIV-uninfected adults with and without COPD (n=76) were profiled for DNA methylation and gene expression. We evaluated global Alu and LINE-1 methylation and calculated the epigenetic age using the Horvath clock and the methylation telomere length estimator. To identify genome-wide differential DNA methylation and gene expression associated with HIV and COPD, robust linear models were used followed by an expression quantitative trait methylation (eQTM) analysis.Epigenetic age acceleration and shorter methylation estimates of telomere length were found in PLWH with COPD compared to PLWH without COPD and uninfected patients with and without COPD. Global hypomethylation was identified in PLWH. We identified 7,970 CpG sites, 293 genes, and 9 eQTM-gene pairs associated with the interaction between HIV and COPD. ABLIM3 was one of the novel candidate genes for HIV-associated COPD highlighted by our analysis.Methylation age acceleration is observed in the airway epithelium of PLWH with COPD, a process that may be responsible for the heightened risk of COPD in this population. Their distinct methylation profile, differing from that observed in patients with COPD alone, suggests a unique pathogenesis to HIV-associated COPD. The associations warrant further investigation to establish causality.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
3秒前
忧郁盼夏完成签到,获得积分10
3秒前
3秒前
搜集达人应助su采纳,获得10
5秒前
丘比特应助gwenjing采纳,获得10
5秒前
哈哈哈完成签到,获得积分10
7秒前
7秒前
冷艳的姿发布了新的文献求助10
7秒前
dpp完成签到,获得积分10
8秒前
周周完成签到,获得积分10
10秒前
11秒前
11秒前
哈哈哈发布了新的文献求助30
11秒前
123发布了新的文献求助10
12秒前
14秒前
Stardust发布了新的文献求助10
14秒前
momo发布了新的文献求助10
15秒前
17秒前
笑笑完成签到,获得积分20
19秒前
stephenzh完成签到,获得积分10
19秒前
su发布了新的文献求助10
21秒前
笑笑发布了新的文献求助10
22秒前
李健的粉丝团团长应助momo采纳,获得10
23秒前
情怀应助LJJ采纳,获得10
25秒前
29秒前
30秒前
30秒前
32秒前
阿里巴巴大盗完成签到,获得积分10
33秒前
zying发布了新的文献求助30
33秒前
传奇3应助muzi采纳,获得10
34秒前
34秒前
34秒前
谢琉圭发布了新的文献求助10
36秒前
wu发布了新的文献求助10
37秒前
打滚完成签到,获得积分10
38秒前
LJJ发布了新的文献求助10
38秒前
睡觉了完成签到 ,获得积分10
40秒前
量子星尘发布了新的文献求助10
41秒前
乖猫要努力应助精明寻梅采纳,获得10
41秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989334
求助须知:如何正确求助?哪些是违规求助? 3531428
关于积分的说明 11253936
捐赠科研通 3270119
什么是DOI,文献DOI怎么找? 1804887
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809173