Airway Aging and Methylation Disruptions in HIV-associated Chronic Obstructive Pulmonary Disease.

慢性阻塞性肺病 DNA甲基化 表观遗传学 医学 甲基化 人口 免疫学
作者
Ana I Hernández Cordero,Chen Xi Yang,Julia Yang,Steven Horvath,Tawimas Shaipanich,Julia MacIsaac,David Ts Lin,Michael S Kobor,Silvia Guillemi,Marianne Harris,Wan Lam,Stephen Lam,Julio Montaner,S F Paul Man,Don D Sin,Janice M Leung
出处
期刊:American Journal of Respiratory and Critical Care Medicine [American Thoracic Society]
标识
DOI:10.1164/rccm.202106-1440oc
摘要

Age-related diseases like chronic obstructive pulmonary disease (COPD) occur at higher rates in people living with human immunodeficiency virus (PLWH), than in uninfected populations.To identify whether accelerated aging can be observed in the airways of PLWH with COPD, manifest by a unique DNA methylation signature.Bronchial epithelial brushings from PLWH with and without COPD and HIV-uninfected adults with and without COPD (n=76) were profiled for DNA methylation and gene expression. We evaluated global Alu and LINE-1 methylation and calculated the epigenetic age using the Horvath clock and the methylation telomere length estimator. To identify genome-wide differential DNA methylation and gene expression associated with HIV and COPD, robust linear models were used followed by an expression quantitative trait methylation (eQTM) analysis.Epigenetic age acceleration and shorter methylation estimates of telomere length were found in PLWH with COPD compared to PLWH without COPD and uninfected patients with and without COPD. Global hypomethylation was identified in PLWH. We identified 7,970 CpG sites, 293 genes, and 9 eQTM-gene pairs associated with the interaction between HIV and COPD. ABLIM3 was one of the novel candidate genes for HIV-associated COPD highlighted by our analysis.Methylation age acceleration is observed in the airway epithelium of PLWH with COPD, a process that may be responsible for the heightened risk of COPD in this population. Their distinct methylation profile, differing from that observed in patients with COPD alone, suggests a unique pathogenesis to HIV-associated COPD. The associations warrant further investigation to establish causality.
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