Cross‐talk of four types of RNA modification writers defines the immune microenvironment in severe asthma

免疫系统 核糖核酸 哮喘 免疫学 先天免疫系统 生物 基因 遗传学
作者
Qibin Lin,Hanxiang Nie,Zhong Zheng,Jieying Zhong,Hanxiang Nie
出处
期刊:Annals of the New York Academy of Sciences [Wiley]
卷期号:1514 (1): 93-103 被引量:3
标识
DOI:10.1111/nyas.14782
摘要

Adenine modifications, including m6 A, m1 A, APA, and A-to-I modifications, are the most impactful RNA modifications. These modifications are primarily produced by enzymes called writers. The main purpose of this study was to explore the cross-talk and potential roles of these writers in severe asthma. We found 13 RNA writers potentially related to severe asthma and three RNA modification patterns. Cluster 3 showed predominant neutrophil infiltration and C-type lectin receptor signaling; cluster 1 showed predominant innate immune cell infiltration and ubiquitin-proteasome system activation; and cluster 2 did not show obvious immune infiltration characteristics. We found that RNA modification writers modified immune cell-related genes and led to both accumulation of different immune cells in the airways and activation of a series of biological processes, which ultimately leads to severe asthma. TRMT6, WTAP, and TRMT6A were included in a random forest model as predictors. Cromoglicic acid, thioperamide, and fluvastatin were potential drugs for clusters 1, 2, and 3, respectively. We found that cross-talk of RNA modifications is significant in severe asthma, which provides insight into severe asthma pathogenesis and possible treatment avenues.
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