Light‐Triggered In Situ Biosynthesis of Artificial Melanin for Skin Protection (Adv. Sci. 7/2022)

Artificial Melanosome for Transdermal Delivery In article number 2103503 by Uk-Jae Lee, Nathaniel S. Hwang, Byung-Gee Kim, and co-workers, light-triggered in situ biosynthesis of artificial melanin in native skin is proposed and demonstrated using photoactivatable tyrosinase. Photoactivatable tyrosinase is synthesized with site-specific incorporation of o-nitrobenzyl tyrosine and then encapsulated into lipid nanoparticles as an artificial melanosome for transdermal delivery. This biomimetic system can recapitulate the biosynthetic analogs of naturally occurring melanin.