亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Clinical Acute Kidney Injury and Histologic Acute Tubular-Interstitial Injury and Their Prognosis in Diabetic Nephropathy

医学 危险系数 内科学 肌酐 急性肾损伤 比例危险模型 胃肠病学 入射(几何) 肾病 糖尿病肾病 泌尿科 内分泌学 糖尿病 物理 光学 置信区间
作者
Qunjuan Lei,Feng Xu,Shuang Liang,Dandan Liang,Jingru Lu,Rong Tang,Xianghui Zhou,Zhihong Liu,Caihong Zeng
出处
期刊:Nephron [Karger Publishers]
卷期号:146 (4): 351-359 被引量:3
标识
DOI:10.1159/000520944
摘要

<b><i>Introduction:</i></b> Histologic acute tubular-interstitial injury (hATI) is often observed in patients with diabetic nephropathy (DN). This study aimed to determine the relationship between hATI and clinical acute kidney injury (cAKI) and evaluate significance of hATI in patients with DN. <b><i>Methods:</i></b> Patients with biopsy-proven DN through 2003–2018 in our center were selected. The prevalence of hATI and its correlations with cAKI, tubular injury biomarkers, and serum creatinine were investigated. The renal survival rates and prognostic factors were analyzed by Kaplan-Meier curve and Cox regression model, respectively. <b><i>Results:</i></b> Of 1,414 patients with DN, 70.4% were male, with a median age of 50.0 years. The incidences of cAKI and hATI were 8.6% and 57.8%, respectively. The severities of most hATI were mild (91.0%). The incidence of cAKI in those with hATI was only 12.2%. The incidences of cAKI positively correlated with the scores of hATI (Kendall <i>r</i> = 0.273, <i>p</i> &#x3c; 0.001). The presence of hATI was related to rapid creatinine rise and increased tubular injury biomarkers although without cAKI. After adjusting for significant covariates, multivariate Cox models showed that patients with hATI alone were one and a half times more likely to develop ESRD (hazard ratio [HR]: 1.46; 95% CI, 1.05–2.02) than those without hATI or cAKI, and patients with hATI plus cAKI were 3 times more likely to develop ESRD (HR: 2.96; 95% CI, 1.85–4.72). <b><i>Conclusion:</i></b> Our findings indicated that hATI was common in patients with DN where the majorities were mild hATI and without cAKI. hATI was an independent risk factor of DN progression, regardless of episodes of cAKI.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
我是老大应助畅快的毛衣采纳,获得10
9秒前
18秒前
20秒前
鲅鱼圈发布了新的文献求助10
23秒前
23秒前
Leofar完成签到 ,获得积分10
30秒前
31秒前
鲅鱼圈完成签到,获得积分10
35秒前
h0jian09完成签到,获得积分10
51秒前
BaooooooMao完成签到,获得积分10
1分钟前
愉快的犀牛完成签到 ,获得积分10
1分钟前
Sunny完成签到,获得积分10
1分钟前
yujie完成签到 ,获得积分10
1分钟前
赘婿应助科研通管家采纳,获得10
2分钟前
2分钟前
西柚柠檬完成签到 ,获得积分10
2分钟前
心系天下完成签到 ,获得积分10
2分钟前
Alex-Song完成签到 ,获得积分0
2分钟前
不秃燃的小老弟完成签到 ,获得积分10
3分钟前
4分钟前
Owen应助科研通管家采纳,获得10
4分钟前
年年有余完成签到,获得积分10
4分钟前
胖小羊完成签到 ,获得积分10
5分钟前
6分钟前
领导范儿应助科研通管家采纳,获得10
6分钟前
6分钟前
juan完成签到 ,获得积分10
7分钟前
学术小垃圾完成签到,获得积分10
7分钟前
叁月二完成签到 ,获得积分10
7分钟前
7分钟前
科研通AI2S应助科研通管家采纳,获得10
8分钟前
大模型应助科研通管家采纳,获得10
8分钟前
xingsixs完成签到 ,获得积分10
8分钟前
AprilLeung完成签到 ,获得积分10
9分钟前
10分钟前
深情安青应助科研通管家采纳,获得10
10分钟前
迷茫的一代完成签到,获得积分10
11分钟前
魔笛的云宝完成签到 ,获得积分10
11分钟前
www完成签到,获得积分10
11分钟前
12分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990423
求助须知:如何正确求助?哪些是违规求助? 3532158
关于积分的说明 11256513
捐赠科研通 3271046
什么是DOI,文献DOI怎么找? 1805207
邀请新用户注册赠送积分活动 882302
科研通“疑难数据库(出版商)”最低求助积分说明 809234