拟南芥
基因座(遗传学)
生物
二聚体
遗传学
拟南芥
蛋白质结构域
锌指
基因
化学
突变体
转录因子
有机化学
作者
Pawan Dahal,Eunju Kwon,Deepak Pathak,Dong Young Kim
标识
DOI:10.1016/j.bbrc.2022.02.025
摘要
CONSTANS is a central protein in the regulation of photoperiodic flowering, which is expressed in response to day length and promotes the expression of Flowering Locus T. The tandem B-box domain in CONSTANS mediates interactions with various proteins to regulate the expression of Flowering Locus T. Although most plants, including Arabidopsis, have multiple B-box proteins, their B-box structures have not been elucidated. Here, we report the crystal structure of a tandem B-box domain from Arabidopsis CONSTANS. The crystal structure shows that each B-box adopts a canonical B-box fold and coordinates two zinc atoms. Furthermore, the crystal structure reveals that the B-box domain has a unique structure that distinguishes it from animal B-boxes at the monomer and dimer level.
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