Exploring the Mechanical Perspective of a New Anti-Tumor Agent: Melatonin

褪黑素 癌症 表观遗传学 生物 免疫系统 癌症研究 松果体 癌细胞 医学 内科学 免疫学 内分泌学 生物化学 基因
作者
Suman Rohilla,Mahaveer Singh,Sakshi Priya,Waleed H. Almalki,Shahril Mohamed Haniffa,Vetriselvan Subramaniyan,Shivkanya Fuloria,Neeraj Kumar Fuloria,Mahendran Sekar,Sachin Kumar Singh,Niraj Kumar Jha,Dinesh Kumar Chellappan,Poonam Negi,Kamal Dua,Gaurav Gupta
出处
期刊:Journal of Environmental Pathology Toxicology and Oncology [Begell House Inc.]
卷期号:42 (1): 1-16 被引量:31
标识
DOI:10.1615/jenvironpatholtoxicoloncol.2022042088
摘要

Melatonin is a serotonin-derived pineal gland hormone with many biological functions like regulating the sleep-wake cycle, circadian rhythm, menstrual cycle, aging, immunity, and antioxidants. Melatonin synthesis and release are more pronounced during the night, whereas exposure to light decreases it. Evidence is mounting in favor of the therapeutic effects of melatonin in cancer prevention, treatment and delayed onset in various cancer subtypes. Melatonin exerts its anticancer effect through modification of its receptors such as melatonin 1 (MT1), melatonin 2 (MT2), and inhibition of cancer cell proliferation, epigenetic alterations (DNA methylation/demethylation, histone acetylation/deacetylation), metastasis, angiogenesis, altered cellular energetics, and immune evasion. Melatonin performs a significant function in immune modulation and enhances innate and cellular immunity. In addition, melatonin has a remarkable impact on epigenetic modulation of gene expression and alters the transcription of genes. As an adjuvant to cancer therapies, it acts by decreasing the side effects and boosting the therapeutic effects of chemotherapy. Since current treatments produce drug-induced unwanted toxicities and side effects, they require alternate therapies. A recent review article attempts to summarize the mechanistic perspective of melatonin in different cancer subtypes like skin cancer, breast cancer, hepatic cancer, renal cell cancer, non-small cell lung cancer (NSCLC), colon oral, neck, and head cancer. The various studies described in this review will give a firm basis for the future evolution of anticancer drugs.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
刚刚
langzi完成签到,获得积分10
刚刚
刚刚
迅速斑马完成签到,获得积分10
刚刚
qq发布了新的文献求助10
1秒前
2秒前
爆米花应助美好斓采纳,获得10
3秒前
小饼饼完成签到 ,获得积分10
3秒前
阿媛呐完成签到,获得积分10
3秒前
嗯嗯完成签到,获得积分10
4秒前
李大龙发布了新的文献求助10
4秒前
四喜丸子完成签到,获得积分10
4秒前
yyy发布了新的文献求助10
5秒前
小胡完成签到,获得积分10
5秒前
研友_VZG7GZ应助研友_LXOJq8采纳,获得10
6秒前
丹丹完成签到,获得积分10
6秒前
6秒前
kilig完成签到,获得积分10
7秒前
8秒前
xia完成签到,获得积分10
8秒前
程程发布了新的文献求助10
8秒前
vovoking完成签到 ,获得积分10
8秒前
8秒前
long0809完成签到,获得积分10
9秒前
顺心的猪完成签到 ,获得积分10
9秒前
充电宝应助飞哥yyds采纳,获得10
10秒前
传奇3应助单纯晋鹏采纳,获得10
10秒前
10秒前
ludy发布了新的文献求助10
10秒前
彭于晏应助沈three采纳,获得10
11秒前
lic完成签到,获得积分10
11秒前
万能图书馆应助通天塔采纳,获得10
11秒前
11秒前
酷波er应助轻松的雪枫采纳,获得10
12秒前
12秒前
嘘嘘完成签到,获得积分10
13秒前
orixero应助复杂的绮兰采纳,获得20
14秒前
盼不热夏完成签到,获得积分10
15秒前
瘦瘦的睫毛膏完成签到,获得积分10
15秒前
高分求助中
Sustainability in Tides Chemistry 1500
Handbook of the Mammals of the World – Volume 3: Primates 805
Ethnicities: Media, Health, and Coping 800
Gerard de Lairesse : an artist between stage and studio 500
Digging and Dealing in Eighteenth-Century Rome 500
Queer Politics in Times of New Authoritarianisms: Popular Culture in South Asia 500
Manual of Sewer Condition Classification 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3069006
求助须知:如何正确求助?哪些是违规求助? 2722831
关于积分的说明 7479538
捐赠科研通 2369753
什么是DOI,文献DOI怎么找? 1256697
科研通“疑难数据库(出版商)”最低求助积分说明 609645
版权声明 596839