Mixed Aliphatic Organozinc Reagents as Nonstabilized Csp3-Nucleophiles in the Multicomponent Mannich Reaction

The use of mixed aliphatic organozinc reagents in the multicomponent Mannich reaction is described. A large variety of primary, secondary, and tertiary organozinc reagents, secondary amines and aromatic or aliphatic aldehydes could be used for the straightforward preparation of densely substituted amines. The three-component reaction could additionally be performed starting from alkyl halides under reductive (Barbier-type) conditions.