化学发光
超氧化物
化学
活性氧
水溶液
衍生工具(金融)
光化学
组合化学
生物化学
有机化学
金融经济学
经济
酶
作者
José Pedro Silva,Patricia González-Berdullas,Joaquim C. G. Esteves da Silva,Luís Pinto da Silva
出处
期刊:Chemosensors
[MDPI AG]
日期:2022-05-05
卷期号:10 (5): 174-174
被引量:5
标识
DOI:10.3390/chemosensors10050174
摘要
Superoxide anion is a reactive oxygen species (ROS) of biological interest. More specifically, it plays a role in intra- and intercellular signaling, besides being associated with conditions such as inflammation and cancer. Given this, efforts have been made by the research community to devise new sensing strategies for this ROS species. Among them, the chemiluminescent reaction of marine Coelenterazine has been employed as a sensitive and dynamic probing approach. Nevertheless, chemiluminescent reactions are typically associated with lower emissions in aqueous solutions. Herein, here we report the synthesis of a new Coelenterazine derivative with the potential for superoxide anion sensing. Namely, this novel compound is capable of chemiluminescence in a dose-dependent manner when triggered by this ROS species. More importantly, the light-emission intensities provided by this derivative were relevantly enhanced (intensities 2.13 × 101 to 1.11 × 104 times higher) in aqueous solutions at different pH conditions when compared to native Coelenterazine. The half-life of the chemiluminescent signal is also greatly increased for the derivative. Thus, a new chemiluminescence molecule with significant potential for superoxide anion sensing was discovered and reported for the first time.
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