维甲酸
化学
抑制性突触后电位
RAR相关孤儿受体γ
立体化学
细胞分化
铅化合物
生物化学
体外
基因
转录因子
生物
内分泌学
作者
Kai‐Long Ji,Jianxin Tang,Zhengyang Guo,Pianchou Gongpan,Peng Sun,Jian‐Mei Lu,Mengyuan Dai,Ting Li
标识
DOI:10.1002/cbdv.202300373
摘要
Abstract Chemical investigation of medicinal plant Glycosmis lucida Wall. ex C. C. Huang leaves led to the production of ten compounds ( 1 – 10 ), including two previously unreported geranylated sulfur‐containing amides ( 1 and 2 ) and eight known ones ( 3 – 10 ). Structural characterization was carried out using comprehensive spectroscopic methods including NMR, MS and CD. The inhibitory effects of all isolates on Th17 differentiation were evaluated, of which compounds 1 and 6 significantly inhibited Th17 differentiation with IC 50 values of 0.36 and 1.30 μM, respectively, while both 1 and 6 failed to bind to retinoic acid‐related orphan receptor gamma t (RORγt), suggesting that their inhibition of Th17 differentiation is independent of RORγt.
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