Quercetin Inhibits Intrahepatic Cholangiocarcinoma by Inducing Ferroptosis and Inhibiting Invasion via the NF-κB Pathway

细胞凋亡 癌症研究 肝内胆管癌 恶性肿瘤 NF-κB 体外 体内 槲皮素 化学 程序性细胞死亡 生物 医学 病理 生物化学 抗氧化剂 生物技术
作者
Yinghui Song,Zhihua Zhang,Qin Chai,Zheng He,Yuchen Qi,Guoyi Xia,Zhangtao Yu,Ranzhiqiang Yang,Junkai Huang,Yuhang Li,Chuang Peng,Bo Jiang,Sulai Liu
出处
期刊:The American Journal of Chinese Medicine [World Scientific]
卷期号:51 (03): 701-721 被引量:3
标识
DOI:10.1142/s0192415x23500337
摘要

Intrahepatic cholangiocarcinoma (ICC) is a rare, highly fatal hepatobiliary malignancy, with very limited treatment options and, consequently, a poor prognosis. Recently, emerging evidence has suggested the potential of quercetin (QE) for use in cancer therapy. The purpose of this study is to investigate whether QE could inhibit ICC. The effects of QE on the proliferation, apoptosis, and invasion of ICC were analyzed in vitro. The inhibitory effect of QE on ICC was also verified in vivo. The RNA sequence was applied to explore the mechanism of QE. Functional verification was also performed after RNA sequencing using activators and inhibitors of nuclear factor-kappa-B (NF-[Formula: see text]B) and ferroptosis. The results showed that QE could inhibit the proliferation and survival of ICC cells, induce the arrest of ICC cells in the G1 phase, promote the apoptosis of ICC cells, and inhibit the invasion of ICC cells. Furthermore, QE could promote ferroptosis in ICC cells by inhibiting the NF-[Formula: see text]B pathway. In conclusion, QE is a new ferroptosis inducer and NF-[Formula: see text]B inhibitor that can not only induce ferroptosis, but also inhibit the invasion of ICC cells, providing a prospective strategy for the treatment of ICC.
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