Age at natural menopause and its associated characteristics among Brazilian women: cross-sectional results from ELSI-Brazil

更年期 医学 比例危险模型 危险系数 腰围 横断面研究 人体测量学 人口学 超重 体重不足 体质指数 外科更年期 老年学 内科学 置信区间 病理 社会学
作者
Nair Tavares Milhem Ygnatios,Juliana Vaz de Melo Mambrini,Juliana Lustosa Torres,Larissa Mendes Dias Detomi,Luciana de Souza Braga,Maria Fernanda Lima‐Costa,Bruno de Souza Moreira
出处
期刊:Menopause [Lippincott Williams & Wilkins]
标识
DOI:10.1097/gme.0000000000002385
摘要

Abstract Objectives This study aimed to determine the median age at natural menopause and analyze lifestyle, anthropometric, and dietary characteristics associated with the age at natural menopause among Brazilian women. Methods This cross-sectional study involved 2,731 women 50 years and over, drawn from the baseline of the Brazilian Longitudinal Study of Aging (ELSI-Brazil, 2015/16). Nonparametric Kaplan-Meier cumulative survivorship estimates were used to assess the median timing of natural menopause. Cox proportional hazards regression models were employed to estimate the associations between age at natural menopause and exposure variables. Results The overall median age at natural menopause was 50 years. In the adjusted Cox model, current smoking (hazard ratio [HR], 1.11; 95% CI, 1.01-1.23) and underweight (HR, 1.34; 95% CI, 1.12-1.61) were associated with earlier natural menopause. Conversely, performing recommended levels of physical activity in the last week (HR, 0.88; 95% CI, 0.80-0.97), being overweight (HR 0.86; 95% CI, 0.74-0.99), and adhering to two or three healthy eating markers (HR, 0.80; 95% CI, 0.66-0.97; HR, 0.76; 95% CI, 0.61-0.94, respectively) were associated with later age at natural menopause. Binge drinking and waist circumference were not associated with age at natural menopause. Conclusions Lifestyle, anthropometric, and dietary characteristics are significant factors that affect the age at natural menopause. Our findings can contribute to public policies targeted at Brazilian women's health.

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