Eugenol Possesses Colitis Protective Effects: Impacts on the TLR4/MyD88/NF-κB Pathway, Intestinal Epithelial Barrier, and Macrophage Polarization

Eugenol (EU) has been shown to ameliorate experimental colitis due to its anti-oxidant and anti-inflammatory bioactivities. In this study, DSS-induced acute colitis was established and applied to clarify the regulation efficacy of EU on intestinal barrier impairment and macrophage polarization imbalance along with the inflammatory response. Besides, the adjusting effect of EU on macrophages was further investigated