产矿性
神经科学
海马结构
海马体
神经肽
生物
心理学
医学
内科学
神经肽Y受体
受体
作者
Daniel A. N. Barbosa,Sandra Gattas,Juliana S. Salgado,Fiene Marie Kuijper,Allan Wang,Yuhao Huang,Bina Kakusa,Christoph Leuze,Artur Luczak,Paul E. Rapp,Robert C. Malenka,Dora Hermes,Kai J. Miller,Boris D. Heifets,Cara Bohon,Jennifer A. McNab,Casey H. Halpern
出处
期刊:Nature
[Springer Nature]
日期:2023-08-30
卷期号:621 (7978): 381-388
被引量:8
标识
DOI:10.1038/s41586-023-06459-w
摘要
Abstract Only recently have more specific circuit-probing techniques become available to inform previous reports implicating the rodent hippocampus in orexigenic appetitive processing 1–4 . This function has been reported to be mediated at least in part by lateral hypothalamic inputs, including those involving orexigenic lateral hypothalamic neuropeptides, such as melanin-concentrating hormone 5,6 . This circuit, however, remains elusive in humans. Here we combine tractography, intracranial electrophysiology, cortico-subcortical evoked potentials, and brain-clearing 3D histology to identify an orexigenic circuit involving the lateral hypothalamus and converging in a hippocampal subregion. We found that low-frequency power is modulated by sweet-fat food cues, and this modulation was specific to the dorsolateral hippocampus. Structural and functional analyses of this circuit in a human cohort exhibiting dysregulated eating behaviour revealed connectivity that was inversely related to body mass index. Collectively, this multimodal approach describes an orexigenic subnetwork within the human hippocampus implicated in obesity and related eating disorders.
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