Friend or foe? Inflammation and the foreign body response to orthopedic biomaterials

炎症 异物巨细胞 免疫系统 植入 异物 医学 先天免疫系统 免疫学 病理 外科
作者
Emmanuel Gibon,Yuya Takakubo,Stefan Zwingenberger,Jiří Gallo,Michiaki Takagi,Stuart B. Goodman
出处
期刊:Journal of Biomedical Materials Research Part A [Wiley]
卷期号:112 (8): 1172-1187 被引量:1
标识
DOI:10.1002/jbm.a.37599
摘要

Abstract The use of biomaterials and implants for joint replacement, fracture fixation, spinal stabilization and other orthopedic indications has revolutionized patient care by reliably decreasing pain and improving function. These surgical procedures always invoke an acute inflammatory reaction initially, that in most cases, readily subsides. Occasionally, chronic inflammation around the implant develops and persists; this results in unremitting pain and compromises function. The etiology of chronic inflammation may be specific, such as with infection, or be unknown. The histological hallmarks of chronic inflammation include activated macrophages, fibroblasts, T cell subsets, and other cells of the innate immune system. The presence of cells of the adaptive immune system usually indicates allergic reactions to metallic haptens. A foreign body reaction is composed of activated macrophages, giant cells, fibroblasts, and other cells often distributed in a characteristic histological arrangement; this reaction is usually due to particulate debris and other byproducts from the biomaterials used in the implant. Both chronic inflammation and the foreign body response have adverse biological effects on the integration of the implant with the surrounding tissues. Strategies to mitigate chronic inflammation and the foreign body response will enhance the initial incorporation and longevity of the implant, and thereby, improve long‐term pain relief and overall function for the patient. The seminal research performed in the laboratory of Dr. James Anderson and co‐workers has provided an inspirational and driving force for our laboratory's work on the interactions and crosstalk among cells of the mesenchymal, immune, and vascular lineages, and orthopedic biomaterials. Dr. Anderson's delineation of the fundamental biologic processes and mechanisms underlying acute and chronic inflammation, the foreign body response, resolution, and eventual functional integration of implants in different organ systems has provided researchers with a strategic approach to the use of biomaterials to improve health in numerous clinical scenarios.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Akim应助天真的皓轩采纳,获得10
2秒前
Venus发布了新的文献求助10
4秒前
张张发布了新的文献求助10
5秒前
哈哈哈哈发布了新的文献求助10
6秒前
lifeng完成签到 ,获得积分10
6秒前
JamesPei应助Venus采纳,获得10
8秒前
10秒前
LXYang完成签到,获得积分10
10秒前
Divya完成签到,获得积分10
11秒前
11秒前
武雨寒完成签到,获得积分20
13秒前
武雨寒发布了新的文献求助10
16秒前
Haiverxin完成签到,获得积分10
17秒前
19秒前
顺心的猪完成签到 ,获得积分10
20秒前
科研通AI2S应助罗是一采纳,获得10
20秒前
wpie99完成签到,获得积分10
22秒前
23秒前
25秒前
28秒前
Owen应助DianaRang采纳,获得30
29秒前
罗是一完成签到,获得积分10
32秒前
科研通AI2S应助三里清风采纳,获得10
33秒前
34秒前
35秒前
35秒前
36秒前
36秒前
小娜娜发布了新的文献求助10
37秒前
jie发布了新的文献求助10
38秒前
40秒前
43秒前
毛毛完成签到,获得积分10
43秒前
43秒前
45秒前
rl完成签到,获得积分10
46秒前
666666666666666完成签到,获得积分10
48秒前
归零儿完成签到,获得积分10
49秒前
天真的皓轩完成签到,获得积分10
49秒前
勤恳函完成签到,获得积分10
49秒前
高分求助中
Sustainability in Tides Chemistry 2800
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Bayesian Models of Cognition:Reverse Engineering the Mind 888
Le dégorgement réflexe des Acridiens 800
Defense against predation 800
Very-high-order BVD Schemes Using β-variable THINC Method 568
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3134988
求助须知:如何正确求助?哪些是违规求助? 2785963
关于积分的说明 7774538
捐赠科研通 2441779
什么是DOI,文献DOI怎么找? 1298177
科研通“疑难数据库(出版商)”最低求助积分说明 625088
版权声明 600825