缺氧(环境)
肿瘤缺氧
纳米医学
重编程
转移
肿瘤微环境
癌症研究
癌症
医学
生物信息学
生物
纳米技术
肿瘤细胞
放射治疗
化学
内科学
材料科学
氧气
细胞
纳米颗粒
遗传学
有机化学
作者
Yi Pan,Longcai Liu,Xiaozhou Mou,Yu Cai
出处
期刊:ACS Nano
[American Chemical Society]
日期:2023-10-23
卷期号:17 (21): 20875-20924
被引量:10
标识
DOI:10.1021/acsnano.3c07763
摘要
Cancer with a complex pathological process is a major disease to human welfare. Due to the imbalance between oxygen (O2) supply and consumption, hypoxia is a natural characteristic of most solid tumors and an important obstacle for cancer therapy, which is closely related to tumor proliferation, metastasis, and invasion. Various strategies to exploit the feature of tumor hypoxia have been developed in the past decade, which can be used to alleviate tumor hypoxia, or utilize the hypoxia for targeted delivery and diagnostic imaging. The strategies to alleviate tumor hypoxia include delivering O2, in situ O2 generation, reprogramming the tumor vascular system, decreasing O2 consumption, and inhibiting HIF-1 related pathways. On the other side, hypoxia can also be utilized for hypoxia-responsive chemical construction and hypoxia-active prodrug-based strategies. Taking advantage of hypoxia in the tumor region, a number of methods have been applied to identify and keep track of changes in tumor hypoxia. Herein, we thoroughly review the recent progress of nanomedicine strategies in both conquering and utilizing hypoxia to combat cancer and put forward the prospect of emerging nanomaterials for future clinical transformation, which hopes to provide perspectives in nanomaterials design.
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