共价键
光热效应
光热治疗
抗氧化剂
伤口愈合
过氧化氢酶
纳米技术
化学
超氧化物歧化酶
基质(水族馆)
材料科学
组合化学
化学工程
生物物理学
有机化学
工程类
免疫学
海洋学
地质学
生物
作者
Jing Wang,Meng Zhang,Yueyue Wang,Wenxin Lv,Xu Zhao,Bo Wang,Rongqin Huang,Bingbao Mei,Yi Wang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2024-12-17
标识
DOI:10.1021/acsnano.4c13899
摘要
Creating simple methods to produce antioxidant nanozymes with clear structure–activity relationships, particularly aiming to improve disinfection and create practical drug formulations for bacterial wound healing, remains a crucial challenge. Herein, we synthesized iron-loaded covalent organic framework nanospheres, which were then controllably transformed into a carbon-based nanozyme with both iron single atoms and iron clusters through simple pyrolysis. We discovered that the gradual growth of iron clusters significantly boosted the nanozyme's adsorption onto the substrate and electron transfer, greatly influencing its activity. The nanozyme, optimized by the coexistence of single iron atoms and Fe4 clusters, exhibited the strongest catalase and superoxide dismutase enzyme activities as well as high photothermal efficiency. Under physiological conditions, its peroxidase and oxidase enzymatic activities, which stimulate oxidative stress, remained low. Furthermore, we created an antibacterial self-gelling powder capable of dispersing the nanozyme using polyacrylamide and poly(acrylic acid). The powder can rapidly gel and adhere to wet wound areas, synergistically sterilizing the wound through the combined actions of the gel's amino groups and the nanozyme's photothermal effect, while leveraging the antioxidant enzymatic effects to mitigate wound inflammation. These properties contribute to the fast healing of infectious wounds, thus promising a clear formulation and treatment.
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