Extravasation of immune and tumor cells from an endothelial perspective

外渗 白细胞外渗 生物 内皮 循环肿瘤细胞 免疫系统 炎症 转移 免疫学 癌症研究 癌症 细胞生物学 病理 医学 内分泌学 遗传学
作者
Amandine Dupas,Jacky G. Goetz,Naël Osmani
出处
期刊:Journal of Cell Science [The Company of Biologists]
卷期号:137 (21) 被引量:1
标识
DOI:10.1242/jcs.262066
摘要

ABSTRACT Crossing the vascular endothelium is a necessary stage for circulating cells aiming to reach distant organs. Leukocyte passage through the endothelium, known as transmigration, is a multistep process during which immune cells adhere to the vascular wall, migrate and crawl along the endothelium until they reach their exit site. Similarly, circulating tumor cells (CTCs), which originate from the primary tumor or reseed from early metastatic sites, disseminate using the blood circulation and also must cross the endothelial barrier to set new colonies in distant organs. CTCs are thought to mimic arrest and extravasation utilized by leukocytes; however, their extravasation also requires processes that, from an endothelial perspective, are specific to cancer cells. Although leukocyte extravasation relies on maintaining endothelial impermeability, it appears that cancer cells can indoctrinate endothelial cells into promoting their extravasation independently of their normal functions. In this Review, we summarize the common and divergent mechanisms of endothelial responses during extravasation of leukocytes (in inflammation) and CTCs (in metastasis), and highlight how these might be leveraged in the development of anti-metastatic treatments.

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