Autoantibody detection is important in the diagnosis, classification, condition assessment and therapeutical effect monitoring of autoimmune disease. To improve the diagnosis and treatment ability of autoimmune disease in primary healthcare institutions in China, Grassroots Inspection Technology Standardization Branch of China International Exchange and Promotive Association for Medical and Health Care organized experts from various clinical specialties, such as the department of laboratory medicine and the department of rheumatology, to publish the "Expert consensus on autoantibody detection and application in primary healthcare institutions", so as to promote the professionalization and standardization of autoantibody detection and application in primary healthcare institutions.