Food-derived peptides as novel therapeutic strategies for NLRP3 inflammasome-related diseases: a systematic review

炎症体 吡喃结构域 点头 环核苷酸结合域 计算生物学 医学 生物 炎症 体内 免疫学 生物化学 生物技术 核苷酸 基因
作者
Ziqi Zhang,Yuan Zhang,Meiying Zhang,Chenfeng Yu,Pingping Yang,Minxuan Xu,Jitao Ling,Yuting Wu,Zicheng Zhu,Yixuan Chen,Ao Shi,Xiao Liu,Jing Zhang,Peng Yu,Deju Zhang
出处
期刊:Critical Reviews in Food Science and Nutrition [Informa]
卷期号:: 1-32 被引量:2
标识
DOI:10.1080/10408398.2023.2294164
摘要

NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3), a member of the nucleotide-binding domain (NOD) and leucine-rich repeat sequence (LRR) protein (NLR) family, plays an essential role in the inflammation initiation and inflammatory mediator secretion, and thus is also associated with many disease progressions. Food-derived bioactive peptides (FDBP) exhibit excellent anti-inflammatory activity in both in vivo and in vitro models. They are encrypted in plant, meat, and milk proteins and can be released under enzymatic hydrolysis or fermentation conditions, thereby hindering the progression of hyperuricemia, inflammatory bowel disease, chronic liver disease, neurological disorders, lung injury and periodontitis by inactivating the NLRP3. However, there is a lack of systematic review around FDBP, NLRP3, and NLRP3-related diseases. Therefore, this review summarized FDBP that exert inhibiting effects on NLRP3 inflammasome from different protein sources and detailed their preparation and purification methods. Additionally, this paper also compiled the possible inhibitory mechanisms of FDBP on NLRP3 inflammasomes and its regulatory role in NLRP3 inflammasome-related diseases. Finally, the progress of cutting-edge technologies, including nanoparticle, computer-aided screening strategy and recombinant DNA technology, in the acquisition or encapsulation of NLRP3 inhibitory FDBP was discussed. This review provides a scientific basis for understanding the anti-inflammatory mechanism of FDBP through the regulation of the NLRP3 inflammasome and also provides guidance for the development of therapeutic adjuvants or functional foods enriched with these FDBP.
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