A new insight into material basis of rhizoma Paridis saponins in alleviating pain

止痛药 药理学 薯蓣皂甙元 医学 化学 有机化学
作者
Shuli Man,Xinghao Zhang,Lu Xie,Yaxue Zhou,Genbei Wang,Ruijia Hao,Wenyuan Gao
出处
期刊:Journal of Ethnopharmacology [Elsevier BV]
卷期号:323: 117642-117642 被引量:2
标识
DOI:10.1016/j.jep.2023.117642
摘要

Paris polyphylla, as a traditional Chinese herbal medicine, was often used to relieve inflammation and pain. Rhizoma Paridis saponins (RPS) as the main active components of Paris polyphylla have excellent analgesic effects. Determine the analgesic material basis of RPS. LC-MS/MS was used to analyze RPS, plasma after intravenous injection of RPS, and oral administration of RPS. H22 plantar pain model was established to explore the analgesic material basis of RPS. Moreover, correlation analysis, network pharmacology, RT-PCR and molecular docking were applied in this research. RPS had dose-dependently analgesic effects in acetic acid- and formalin-induced pain models. LC-MS/MS detection indicated that diosgenin as the metabolite of RPS mainly distributed in brain tissues. The addition of antibiotics increased the anti-tumor effect of RPS, but reduced its analgesic effect. Network pharmacology, RT-PCR and molecular docking showed that diosgenin exerted its analgesic effect through SRC and Rap1 signaling pathway. Diosgenin exhibited analgesic effects, while saponins had good anti-tumor effects in RPS. This discovery provided a better indication for the later application of RPS in anti-tumor and analgesic settings.
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