A novel variant with a severe phenotype in a patient with CARD14-associated papulosquamous eruption successfully treated with ixekizumab

CARD14-associated papulosquamous eruption (CAPE) is an autosomal dominant disorder characterized by early onset of symptoms, prominent facial involvement, clinical manifestations resembling both psoriasis and pityriasis rubra pilaris (PRP), family history of psoriasis or PRP and limited response to conventional topical and systemic therapies for psoriasis or PRP. Here, we describe the clinical features of a patient with CAPE and a novel mutation of CARD14.