衰老
血管平滑肌
SIRT6型
炎症
血管生成
体内
腹主动脉瘤
医学
发病机制
体外
腹主动脉
主动脉瘤
主动脉
癌症研究
内科学
平滑肌
化学
生物
动脉瘤
外科
生物化学
酶
生物技术
锡尔图因
NAD+激酶
作者
Le Yang,Xuejun Wu,Shuai Bian,Dongfang Zhao,Sheng Fang,Hai Tao Yuan
出处
期刊:Atherosclerosis
[Elsevier BV]
日期:2024-02-24
卷期号:392: 117483-117483
被引量:4
标识
DOI:10.1016/j.atherosclerosis.2024.117483
摘要
Background and aims In this study, we carried out a clinical sample study, and in vivo and in vitro studies to evaluate the effect of SIRT6 and SIRT6-mediated vascular smooth muscle senescence on the development of abdominal aortic aneurysm (AAA). Method and Results AAA specimen showed an increased P16, P21 level and a decreased SIRT6 level compared with control aorta. Time curve study of Ang II infusion AAA model showed similar P16, P21 and SIRT6 changes at the early phase of AAA induction. The in vivo overexpression of SIRT6 significantly prevented AAA formation in Ang II infusion model. The expression of P16 and P21 was significantly reduced after SIRT6 overexpression. SIRT6 overexpression also attenuated chronic inflammation and neo-angiogenesis in Ang II infusion model. The overexpression of SIRT6 could attenuate premature senescence, inflammatory response and neo-angiogenesis in human aortic smooth muscle cells (HASMC) under Ang II stimulation. Conclusions SIRT6 overexpression could limit AAA formation via attenuation of vascular smooth muscle senescence, chronic inflammation and neovascularity.
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