Dendritic cell-cytokine killer combined with microwave ablation reduced recurrence for hepatocellular carcinoma compared to ablation alone

医学 肝细胞癌 微波消融 免疫疗法 内科学 细胞因子诱导的杀伤细胞 胃肠病学 肿瘤科 CD8型 免疫系统 癌症 烧蚀 免疫学 CD3型
作者
Luo Wang,Xin Li,Xuejuan Dong,Xiaoling Yu,Jing Zhang,Zhigang Cheng,Zhiyu Han,Fangyi Liu,Jie Yu,Ping Liang
出处
期刊:Technology and Health Care [IOS Press]
卷期号:32 (3): 1819-1834 被引量:4
标识
DOI:10.3233/thc-230871
摘要

BACKGROUND: Several international practice guidelines have recommended local ablation as the first-line treatment for early-stage hepatocellular carcinoma (HCC). OBJECTIVE: This study aims to investigate the synergetic anti-tumor impact of dendritic cell-cytokine killer (DC-CIK) combined with microwave ablation (MWA) for HCC. METHODS: This retrospective study included 1,141 patients from the American Joint Committee on Cancer stage I-II HCC, who were treated with therapeutic MWA. The immunotherapy group encompassing 40 patients received additional immunotherapy with DC-CIK, whereas the control group consisting of 1,101 patients was treated with MWA alone. Propensity score matching (PSM) with ratio of 1:3 was employed to balance selection bias. The oncological outcome and immune status were measured after combination therapy. RESULTS: The immunotherapy group patients exhibited significant longer disease-free survival (DFS, primary HCC: p= 0.036; recurrent HCC: p= 0.026). For patients with primary HCC, the recurrence frequency was reduced (p= 0.002), and recurrence interval (19 months vs. 9 months, p< 0.001) was prolonged in the immunotherapy group. Subgroup analysis revealed that patients ⩽ 60 years old, moderately-differentiated HCC, or co-infected with Hepatitis B Virus (HBV) had a significant benefit over DFS in the immunotherapy group. After combination therapy, the serum CD3+ (p= 0.049), CD8/CD28+ (p= 0.045) were elevated. CONCLUSION: Combination therapy with DC-CIK and MWA can significantly reduce the recurrence and prolong DFS, especially for patients ⩽ 60 years old or with moderately-differentiated HCC or co-infected with HBV.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
emmm完成签到 ,获得积分10
1秒前
十三发布了新的文献求助10
1秒前
2秒前
2秒前
liangmh完成签到,获得积分10
2秒前
一二不休完成签到,获得积分10
2秒前
123发布了新的文献求助10
3秒前
5秒前
ding应助黑熊安巴尼采纳,获得10
6秒前
Ava应助wjxcl采纳,获得10
6秒前
闪闪如南发布了新的文献求助10
6秒前
深情安青应助一二不休采纳,获得10
7秒前
9秒前
123完成签到,获得积分10
9秒前
不扯先生完成签到,获得积分10
10秒前
柳絮完成签到,获得积分20
11秒前
lll完成签到,获得积分10
11秒前
sdl完成签到,获得积分10
11秒前
Orange应助孟婆的碗采纳,获得10
12秒前
zhangmy1989发布了新的文献求助30
12秒前
12秒前
清秀的不言完成签到 ,获得积分10
12秒前
杂化轨道退役研究员完成签到,获得积分10
12秒前
FashionBoy应助tanglu采纳,获得10
13秒前
14秒前
闪闪如南完成签到,获得积分10
15秒前
wjxcl完成签到,获得积分10
16秒前
16秒前
16秒前
12233完成签到,获得积分10
17秒前
17秒前
洪武完成签到,获得积分20
17秒前
18秒前
Yuantian发布了新的文献求助10
19秒前
传奇3应助浪花淘尽英雄采纳,获得10
20秒前
流川枫完成签到,获得积分10
20秒前
赘婿应助leo采纳,获得10
20秒前
追寻夏烟完成签到 ,获得积分10
21秒前
闪闪寒云完成签到 ,获得积分10
21秒前
13633501455完成签到 ,获得积分10
22秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038569
求助须知:如何正确求助?哪些是违规求助? 3576279
关于积分的说明 11374944
捐赠科研通 3305979
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892698
科研通“疑难数据库(出版商)”最低求助积分说明 815048