化学选择性
化学
催化作用
亲核细胞
过硫酸钾
过硫酸盐
苯甲醇
有机化学
选择性
钾
药物化学
聚合
聚合物
作者
Peng Huang,Guangan Zhang,Zechao Wang,Junliang Wu
标识
DOI:10.1002/asia.202300425
摘要
Alkoxylation of benzylic C(sp3 )-H bonds has become one of the most important tools for the construction of benzyl ethers from feedstock chemicals. Herein, we reported a silver catalyzed alkoxylation of benzylic C(sp3 )-H bonds employing potassium persulfate as an oxidant at room temperature. This strategy showed good functional-group tolerance, site selectivity, and chemoselectivity. The reaction proceeded smoothly in the presence of various primary, secondary, and tertiary alcohol nucleophiles, affording corresponding benzyl ethers. Combined experimental studies provided mechanistic insights into the possible radical pathways. Furthermore, a possible mechanism was proposed for this method.
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