孟德尔随机化
前列腺癌
置信区间
优势比
医学
肿瘤科
前列腺
癌症
内科学
基因
生物
遗传学
遗传变异
基因型
作者
Jie Zheng,Jieli Lu,Jiying Qi,Qian Yang,Huiling Zhao,Haoyu Liu,Zhihe Chen,Lanhui Huang,Youqiong Ye,Min Xu,Yu Xu,Tiange Wang,Mian Li,Zhiyun Zhao,Ruizhi Zheng,Shuangyuan Wang,Hong Lin,Chunyan Hu,Celine Sze Ling Chui,Shiu Lun Au Yeung
标识
DOI:10.1016/j.xcrm.2024.101688
摘要
We evaluated the effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on prostate cancer by evidence triangulation. Using Mendelian randomization, we found that genetically proxied SGLT2 inhibition reduced the risk of overall (odds ratio = 0.56, 95% confidence interval [CI] = 0.38 to 0.82; 79,148 prostate cancer cases and 61,106 controls), advanced, and early-onset prostate cancer. Using electronic healthcare data (n
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