The current scenario of naturally occurring indole alkaloids with anticancer potential

Naturally occurring indole alkaloids are ubiquitously present in nature and possess extensive biological properties and structural diversity. Mechanistically, naturally occurring indole alkaloids have the potential to inhibit cancer cell proliferation, arrest cell cycle and induce apoptosis. Accordingly, naturally occurring indole alkaloids exhibit promising activity against both drug-sensitive and drug-resistant cancers including multidrug-resistant forms. Therefore, naturally occurring indole alkaloids constitute an important source of anticancer drug leads and candidates. The goal of this review is to highlight the current scenario of naturally occurring indole alkaloids with anticancer potential, covering articles published from 2018 to present. The names, sources, and antiproliferative activity are discussed to continuously open up a map for the remarkable exploration of more effective candidates.