微乳液
黄腐酚
溶解度
增溶
化学
药物输送
水溶液
抗氧化剂
输送系统
扩散
化学工程
色谱法
药理学
有机化学
生物化学
计算机科学
热力学
肺表面活性物质
医学
物理
工程类
钥匙(锁)
计算机安全
作者
Jingyang Luo,Bowen Yang,Xiaoling Yang,Shengyang Ji,Zefeng Guo,Yan Liu,Qi Chen,Tian Zhao,Wentao Wang,Baiyi Lu
出处
期刊:Food Chemistry
[Elsevier]
日期:2023-02-03
卷期号:413: 135631-135631
被引量:8
标识
DOI:10.1016/j.foodchem.2023.135631
摘要
Xanthohumol (XN) has numerous compelling physiological activities, but the poor solubility and stability severely limit its utilization. Therefore, a microemulsion (ME) delivery system based on biosurfactant sophorolipids (SLs) was established and its improvement on physicochemical properties of XN was investigated. The results showed that the systems increased the solubility of XN by about 4000 times, and its half-life during storage was extended to over 150 days. Partial replacement of Tween 80 with SL did not greatly affect their ability to form O/W subregions (in the high aqueous phase), but further improved the solubilization efficiency, storage stability, and antioxidant properties of XN. In vitro models revealed the release profile of XN from the systems followed non-Fickian diffusion, and the ME structure markedly strengthened its digestive stability and bioaccessibility. These results indicated that SL-based ME systems had great potential as a green solubilization and delivery method for XN and other hydrophobic drugs.
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