化学
羟醛反应
催化作用
羟醛缩合
有机化学
脯氨酸
醛
丙酮
有机催化
环己酮
对映选择合成
产量(工程)
作者
Alberto Martínez,Kristina Zumbansen,Arno Döhring,Manuel van Gemmeren,Benjamin List
出处
期刊:Synlett
[Georg Thieme Verlag KG]
日期:2014-03-25
卷期号:25 (07): 932-934
被引量:20
标识
DOI:10.1055/s-0033-1340919
摘要
The proline-catalyzed asymmetric aldol reaction between aliphatic aldehydes and acetone has, to date, remained underdeveloped. Challenges in controlling this reaction include avoiding undesired side reactions such as aldol condensation and self-aldolization. In recent years we have developed optimized conditions, which enable high yields and good to excellent enantioselectivities, and which are presented in this communication.
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