美金刚
NMDA受体
外壳蛋白
药理学
体外
谷氨酸受体
神经科学
受体
医学
化学
生物
生物化学
内科学
核糖核酸
基因
出处
期刊:Neurology
[Ovid Technologies (Wolters Kluwer)]
日期:1992-07-01
卷期号:42 (7): 1403-1403
被引量:153
标识
DOI:10.1212/wnl.42.7.1403
摘要
Studies with in vitro model systems suggest that at least part of the neurologic deficits of human immunodeficiency virus (HIV)-1-associated cognitive/motor complex may stem from neuronal injury mediated by the HIV-1 coat protein gp120. Concurrent activation of N-methyl-D-aspartate (NMDA) receptors is also necessary for gp120 to induce neuronal damage. We studied memantine, a drug that blocks NMDA receptor-operated ion channels, for possible protective effects from gp120-induced neuronal injury. In identified rat retinal ganglion cells in culture, we found that 2 microM memantine completely prevented the injury engendered by 20 pM gp120. These data suggest that memantine has therapeutic potential as an NMDA antagonist capable of ameliorating neuronal damage associated with gp120.
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