Fc receptors for immunoglobulin G—a role in the pathogenesis of Guillain–Barré syndrome and multiple sclerosis

Receptors for the Fc part of IgG (FcγR) constitute a family of cell-surface molecules expressed on almost every cell of the immune system. They are also present on non-lymphoid cells such as Schwann cells and endothelial cells. By linking humoral and cell-mediated responses, FcγR are key in defending against pathogens. Polymorphisms in some FcγR genes are associated with infectious and autoimmune diseases. It was found recently that certain FcγRIIA and FcγRIIIB allotypes are correlated with the disease course of Guillain–Barré syndrome (GBS) and multiple sclerosis (MS). This may imply that clearance of circulating autoantibodies and immune complexes is important in the pathogenesis of these diseases.