Noninvasive OCT imaging of the retinal morphology and microvasculature based on the combination of the phase and amplitude method

光学相干层析成像 视网膜 脉络膜 滤波器(信号处理) 光学 视网膜 振幅 血流 相(物质) 计算机科学 分割 材料科学 计算机视觉 人工智能 生物医学工程 物理 医学 内科学 眼科 量子力学
作者
Qin Lin,Shanhui Fan,Chuanqing Zhou
出处
期刊:Journal of Modern Optics [Taylor & Francis]
卷期号:64 (7): 760-770 被引量:1
标识
DOI:10.1080/09500340.2016.1260779
摘要

To implement the optical coherence tomography (OCT) angiography on the low scanning speed OCT system, we developed a joint phase and amplitude method to generate 3-D angiograms by analysing the frequency distribution of signals from non-moving and moving scatterers and separating the signals from the tissue and blood flow with high-pass filter dynamically. This approach firstly compensates the sample motion between adjacent A-lines. Then according to the corrected phase information, we used a histogram method to determine the bulk non-moving tissue phases dynamically, which is regarded as the cut-off frequency of a high-pass filter, and separated the moving and non-moving scatters using the mentioned high-pass filter. The reconstructed image can visualize the components of moving scatters flowing, and enables volumetric flow mapping combined with the corrected phase information. Furthermore, retinal and choroidal blood vessels can be simultaneously obtained by separating the B-scan into retinal part and choroidal parts using a simple segmentation algorithm along the RPE. After the compensation of axial displacements between neighbouring images, three-dimensional vasculature of ocular vessels has been visualized. Experiments were performed to demonstrate the effectiveness of the proposed method for 3-D vasculature imaging of human retina and choroid. The results revealed depth-resolved vasculatures in retina and choroid, suggesting that our approach can be used for noninvasive and three-dimensional angiography with a low-speed clinical OCT, and it has a great potential for clinic application.
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